Company
Location
Oxford, England - United Kingdom
Job type
Full-Time
Python Job Details
About the role
Applications are invited for a Bioinformatician for the Oxford Molecular Diagnostics Centre (OMDC), based at the Department of Oncology, University of Oxford. The focus of the OMDC is to develop, validate and provide cutting-edge genomics technologies for a range of cancers, with an emphasis on translating research in cancer genomics to the clinic to inform the diagnosis and treatment of patients. The Centre is a fully clinically accredited laboratory that operates in close collaboration with the NHS Oxford University Hospitals.
Current research programmes in OMDC focus on:
(1) generating multiple data modalities from different types of cancers through the application of targeted and whole genome sequencing technologies
(2) adapting these technologies for the analysis of circulating tumour DNA for the detection of early cancer stages and monitoring of minimal residual disease, and
(3) the development of bioinformatics and statistical methodologies for the analysis of these multi-omics datasets for predicting the presence of cancer and/or the risk of progression
In this role, you will analyse whole genome, epigenome and transcriptome sequencing data from a range of research programmes, from different sequencing platforms, and from different types of clinical material (fresh tissue, formalin fixed paraffin embedded, plasma DNA etc), and you will co-author research papers in peer-reviewed scientific journals.
You will apply bioinformatics and statistical analysis methods in close liaison with the Lead and Senior Bioinformaticians, and work on setting up and maintaining the necessary data processing pipelines. You will perform these analyses in the OMDC’s or Genomics England’s HIPAA-compliant AWS environments. You will also contribute to maintaining and further developing the web interfaces that are in-place for delivering the results from the data analyses. Relevant sequence data will be generated in-house or from external providers, in particular Genomics England. You will also work on data from out-sourced sequencing projects for interpretation programmes of activity linked to the OMDC.
The post will be based in the Oxford Molecular Diagnostics Centre (OMDC), John Radcliffe Hospital, Headington, Oxford, OX3 9DU.
The post is offered full-time, fixed-term for two years in the first instance.
About you
You will hold a PhD (Grade 7) or MSc (Grade 6) in Bioinformatics, Biostatistics, Statistical Genetics, Biological or Medical Sciences, Engineering, or similar discipline with a strong quantitative background as well as strong programming skills in at least one scripting language, such as Python or R. Experience working with Linux/Unix systems and experience with relational databases is essential.
Experience of developing, improving and maintaining bioinformatics pipelines using a workflow management system (such as Snakemake or Nextflow) and demonstrable commitment to code quality, version control, and secure data management would be advantageous.
Application Process
You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.
Only applications received by 12:00 pm BST on Monday 11 July 2022 can be considered. Interviews will take place within two weeks of the application closing date.
If you have any questions about this role, please contact Dimitris Vavoulis ([email protected])
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